Ancla C., Lapeyre V., Gosse I., Catargi B., Ravaine V.
Langmuir 2011, 27, 12693-12701

We report on the synthesis of various glucose-responsive microgels based on N-alkylacrylamide derivatives and phenylboronic acid (PBA) as a glucose sensing moiety. Depending on their chemical composition, the microgels exhibit opposite behaviors in response to glucose concentration increase: they can either swell or shrink, using two different mechanisms for glucose recognition. Both behaviors may be suitable for glucose sensing and insulin delivery. When glucose binds a single boronate receptor, the microgel swells as glucose concentration increases. This mechanism can be used to deliver a drug by diffusion through the network. In other cases, glucose binds specifically to two boronates, which creates additional cross-links within the network and provokes shrinkage. Such systems are promising for the development of sensors with improved selectivity and also as potential 'intelligent' valves in microfabricated delivery systems. By a rational choice of the constituting units of the network structure, we show how to favor one or the other type of response to glucose variation. Therefore, glucose-swelling microgels operating under physiological conditions have been obtained by copolymerization, with an appropriate choice of alkylacrylamide monomer, and boronate derivative. At a pH above the pKa of the boronic acid derivative, the same structures shrink in response to glucose concentration. The nature of the cross-linker is a key parameter to enable this dual behavior. In other microgels, an amine group is introduced in the vicinity of the boronic acid, which lowers its pKa and favors microgel contraction at physiological pH. This work has allowed us to give some general rules to control the swelling/shrinking behavior of glucose-responsive microgels.

2011-24

 

Clogging by sieving in microchannels: application to the detection of contaminants in colloidal suspensions
Friday, 08 April 2016
A. Sauret, E. C. Barney, A. Perro, E. Villermaux, H. A. Stone and E. Dressaire  Applied Physics Letters 2014, 105, 074101  We report on a microfluidic method that...
Read More...
Readily Prepared Dynamic Hydrogels by Combining Phenyl Boronic Acid- and Maltose-Modified Anionic Polysaccharides at Neutral pH
Friday, 19 December 2014
D. Tarus, E. Hachet, L. Messager, B. Catargi, V. Ravaine, R. Auzély-Velty Macromol. Rapid. Commun. 2014, 35, 2089 -2095 Dynamic covalent hydrogels are facilely prepared from biocompatible...
Read More...
Impact of Electrostatics on the Adsorption of Microgels at the Interface of Pickering Emulsions
Friday, 19 December 2014
P. Masse, E. Sellier, V. Schmitt, and V. Ravaine Langmuir, 2014, 30 (49), pp 14745–14756 The importance of electrostatics on microgel adsorption at a liquid interface is studied, as well as its...
Read More...
Wireless Electrosampling of Heavy Metals for Stripping Analysis with Bismuth-Based Janus Particles
Wednesday, 19 November 2014
H. Sopha, J. Roche, I. Švancara, A. Kuhn Anal.Chem. 2014, 86, 10515–10519 In this contribution, a wireless method for the electrolytic sampling of heavy metals at special bismuth-modified...
Read More...
Wireless powering of e-swimmers
Tuesday, 21 October 2014
J. Roche, S. Carrara, J. Sanchez, J. Lannelongue, G. Loget, L. Bouffier, P. Fischer, A. Kuhn Sci. Rep. 2014, 4, 6705 Miniaturized structures that can move in a controlled way in solution and...
Read More...
Stimuli-responsive microgels for electrochemiluminescence amplification
Tuesday, 07 October 2014
F. Pinaud, N. Sojic, V. Ravaine L'Actualité Chimique, 2014, 390. In the present work, redox thermoresponsive microgels bearing ruthenium complex were synthesized. Investigation of electrogenerated...
Read More...
Physico-chemical Milling for controlled Size Reduction of Metal Beads
Thursday, 28 August 2014
J. Roche, E. Gianessi, A. Kuhn Phys. Chem. Chem. Phys. 2014, 16, 21234-21236. Here we report a new physico-chemical method based on bipolar electrochemistry for producing spherical metal beads with a...
Read More...
Asymmetric Modification of TiO2 Nanofibers with Gold by Electric-Field-Assisted Photochemistry
Thursday, 31 July 2014
M. Ongaro, J. Roche, A. Kuhn, P. UgoChem. Electro. Chem. 2014, 2048-2051 We present a new procedure for the site-specific deposition of metal on semiconductor nanofibers (NF). The semiconductor NFs...
Read More...
Electrochemiluminescent Swimmers for Dynamic Enzymatic Sensing
Monday, 30 June 2014
M. Sentic, S. Arbault, B. Goudeau, D. Manojlovic, A. Kuhn, L. Bouffier, N. SojicChem. Commun. 2014, 50, 10202-10205. An electrochemiluminescent (ECL) swimmer driven by bipolar electrochemistry is...
Read More...
Monitoring Electrochemically the Early Events of Hydrogen peroxide Production by Mitochondria
Thursday, 22 May 2014
E. Suraniti, S. Ben-Amor, P. Landry, M. Rigoulet, E. Fontaine, S. Bottari, A. Devin, N. Sojic, N. Mano, S. ArbaultAngew. Chem. Int. Ed. 2014, 126, 6773-6776.Mitochondria consume oxygen at the...
Read More...
Electropolymerization of Polypyrrole by Bipolar Electrochemistry in an Ionic Liquid
Tuesday, 13 May 2014
S. Kong, O. Fontaine, J. Roche, L. Bouffier, A. Kuhn, D. ZigahLangmuir 2014, 30, 2973−2976 Bipolar electrochemistry has been recently explored for the modification of conducting micro- and...
Read More...
Adsorption of Microgels at an Oil–Water Interface: Correlation between Packing and 2D Elasticity
Friday, 25 April 2014
F. Pinaud, K. Geisel, P. Massé, B. Catargi, L. Isa, W. Richtering, V. Ravaine, V. SchmittSoft Matter, 2014, in press. The aim of this paper is to determine how microgels adsorb at a model...
Read More...
Imaging Redox Activity at Bipolar Electrodes by Indirect Fluorescence Modulation
Friday, 21 March 2014
Bouffier L., Doneux T., Goudeau B., Kuhn A.Anal. Chem. 2014, 86(8) 3708-3711. Bipolar electrochemistry (BPE) is nowadays well-known but relatively underexploited and still considered as...
Read More...
Site-Selective Synthesis of Janus-type Metal-Organic Framework Composites
Thursday, 06 March 2014
Yadnum S., Roche J., Lebraud E., Négrier P., Garrigue P., Bradshaw D., Warakulwit C., Limtrakul J., Kuhn A. Angew. Chem. Int. Ed. 2014, 126, 4082-4086. Herein, bipolar electrochemistry is applied in...
Read More...
Mapping the Electrogenerated Chemiluminescence Reactivity in Space: Mechanistic Insight into Model Systems Used in Immunoassays
Monday, 03 March 2014
Sentic, M., Milutinovic, M., Kanoufi, F., Manojlovic, D., Arbault S., Sojic, N.Chem. Sci. 2014, 5, 2568-2572. The remarkable characteristics of electrogenerated chemiluminescence (ECL) as a readout...
Read More...
Enantioselective Recognition at Mesoporous Chiral Metal Surfaces
Wednesday, 19 February 2014
Wattanakit C., Bon Saint-Côme Y., Lapeyre V., Bopp P., Heim M., Yadnum S., Nokbin S., Warakulwit C., Limtrakul J., Kuhn A.Nature Comm. 2014, 5, article 3325. Chirality is widespread in natural...
Read More...
Straight-forward Synthesis of Ringed Particles
Thursday, 23 January 2014
Roche J., Loget G., Zigah D., Fattah Z., Goudeau B., Arbault S., Bouffier L., Kuhn A.Chem. Sci. 2014, 5, 1961-1966 Particles with sophisticated surface patterns have many potential applications...
Read More...
Impact of pNIPAM Microgel Size on their Ability to stabilize Pickering Emulsions
Wednesday, 22 January 2014
Destribats M., Lapeyre V., Sellier E., Varga I., Ravaine V., Schmitt V.Langmuir 2014, 30, 1768-1777. We study the influence of the particle size on the ability of poly(N-isoprolylacrylamide)...
Read More...
Asymmetrical Modification of Carbon Microfibers by Bipolar Electrochemistry in Acetonitrile
Friday, 10 January 2014
Ongaro M., Gambirasi A., Favaro M., Kuhn A., Ugo P.Electrochim. Acta 2014, 116, 421. This contribution presents the asymmetrical modification of carbon microfibers (CMF) with gold and polythiophene...
Read More...
Thiol-ene Clickable Hyaluronans: from Macro- to Nanogel
Wednesday, 25 December 2013
Hachet E., Sereni N., Pignot-Paintrand I., Ravaine V., Szarpak-Jankowska A., Auzély-Velty R.J. Coll. Interface Sci. 2014, 419, 52-55. The fabrication of hyaluronic acid (HA) nanogels using a...
Read More...
Enhanced Detection of Hydrogen Peroxide with Platinized Microelectrode Arrays for Analyses of Mitochondria Activities
Sunday, 01 December 2013
Ben-Amor S., Vanhove E., Sékli Belaïdi F., Charlot S., Colin D., Rigoulet M., Devin A., Sojic N., Launay J., Temple-Boyer P., Arbault S. Electrochimica Acta 2014, ASAP article Black...
Read More...
Electrochemical Transduction of DNA Hybridization at Modified Electrodes by using an Electroactive Pyridoacridone Intercalator
Thursday, 12 September 2013
Bouffier L., Wang B. S., Roget A., Livache T., Demeunynck M., Mailley P.Anal. Bioanal. Chem. 2014, 406(4), 1163-1172. A synthetic redox probe structurally related to natural pyridoacridones was...
Read More...
Optical Microwell Array for Large Scale Studies of Single Mitochondria Metabolic Responses
Sunday, 28 July 2013
Vajrala V. S., Suraniti E., Garrigue P., Goudeau B., Rigoulet M., Devin A., Sojic N., Arbault S.Anal. Bioanal. Chem. 2014, 406, 931-941. Forefront Paper Microsystems based on microwell arrays have...
Read More...
Lighting up Redox Propulsion with Luminol Electrogenerated Chemiluminescence
Monday, 08 July 2013
Bouffier L., Zigah D., Adam C., Sentic M., Fattah Z., Manojlovic D., Kuhn A., Sojic N.ChemElectroChem 2014, 1(1), 95-98. A blue-light-emitting swimmer driven by bipolar electrochemistry is reported...
Read More...