Bouffier L., Gosse I., Demeunynck M., Mailley P.,
Bioelectrochemistry 2012, 88, 103-109.

We report here the electrochemical characterization of eight synthetic DNA intercalators based on the 4H-pyrido[4,3,2-kl]acridin-4-one structure. We found that the electrochemical behavior of these redox active drugs is strongly influenced by the nature of the solvent. A single two-electron reduction is observed in an aqueous phosphate buffer (PB) whereas two successive one-electron reductions are observed in aprotic solution (acetonitrile). The influence of the molecular structure on the potential values is addressed along with a comparison between the DNA binding constant (KDNA) and the cytotoxic activity against HT29 cells (IC50). For typical DNA intercalators, one could expect that toxicity will be roughly proportional to the DNA binding constant. Yet, a structure/activity comparison solely based on the DNA affinity was not conclusive. In contrast, a direct relationship was evidenced for the first time between the decimal logarithm of the in vitro bioactivity and the reduction potential of pyridoacridones recorded in PB at pH 7.0. Moreover, most of the bio/electrochemical relationships previously described for quinone-based drugs were reported with electrochemical characterization in aprotic solvents (typically acetonitrile, dimethylformamide or dimethylsulfoxide). But aqueous solution electrochemistry is definitely the most bio-relevant because the redox mechanism of quinone or iminoquinone reduction directly depends on the protic nature of the solvent.

 

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Redox- and pH-Responsive Nanogels Based on Thiolated Poly(aspartic acid)
Monday, 25 July 2016
Enikő Krisch, Léa Messager, Benjámin Gyarmati, Valérie Ravaine, and András Szilágyi Macromol. Mater. Eng. 2016, 301(3), 260–266 Nanogels loaded with fluorescent dextran as a model drug are...
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Wall slip across the jamming transition of soft thermoresponsive particles
Monday, 25 July 2016
Thibaut Divoux, Véronique Lapeyre, Valérie Ravaine, and Sébastien Manneville Phys. Rev. E 2015, 92, 060301(R) Flows of suspensions are often affected by wall slip, that is, the fluid velocity Vf...
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Differential Photoluminescent and Electrochemiluminescent Behavior for Resonance Energy Transfer Processes in Thermoresponsive Microgels
Monday, 25 July 2016
Florent Pinaud, Romain Millereux, Pierre Vialar-Trarieux, Bogdan Catargi, Sandra Pinet, Isabelle Gosse, Neso Sojic, Valérie Ravaine J. Phys. Chem. B, 2015, 119 (40), pp 12954–12961...
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One-Step Preparation of Bifunctionalized Surfaces by Bipolar Electrografting
Wednesday, 30 December 2015
L. Koefoed, K. Shimizu, S. U. Pedersen, K. Daasbjerg, A. Kuhn, and D. Zigah RSC Adv., 2015, DOI: 10.1039/c5ra20156j Bipolar electrochemistry (BPE) is widely used to trigger electrochemical reactions...
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Original Dual Microelectrode: Writing and Reading a local click reaction with Scanning Electrochemical Microscopy
Thursday, 05 November 2015
V. Badets, D. Duclos, D. Quinton, O. Fontaine, D. Zigah Electrochimica Acta, 2015, doi:10.1016/j.electacta.2015.10.066 A dual gold-copper microelectrode (diameter 25 μm) was fabricated to be...
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Electrogenerated Chemiluminescence of Cationic Triangulene Dyes: Crucial Influence of the Core Heteroatoms
Thursday, 05 November 2015
C. Adam, A. Wallabregue, H. Li, J. Gouin, R. Vanel, S. Grass, J. Bosson, L. Bouffier, J. Lacour and N. Sojic. Chem. Eur. J., 2015, 21, 19243-19249. Trianguleniums are fascinating conjugated...
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Solid-State Bipolar Electrochemistry: Polymer-Based Light-Emitting Electrochemical Cells
Thursday, 05 November 2015
S. Chen, G. Wantz, L. Bouffier and J. Gao. ChemElectroChem, 2016, 3, 392-398. We present solid-state, polymer-based, light-emitting electrochemical cells incorporating bipolar electrodes (BPEs)...
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Friday, 25 September 2015
E. Pedraza, A. Karajić, M. Raoux, R. Perrier, A. Pirog, F. Lebreton, S. Arbault, J. Gaitan, S. Renaud, A. Kuhn, J. Lang Lab Chip, 2015, 15, 3880–3890 We are developing a cell-based bioelectronic...
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Wednesday, 23 September 2015
M. Valetaud, G. Loget, J. Roche, N. Hüsken, Z. Fattah, V. Badets, O. Fontaine, D. Zigah. J. Chem. Educ., 2015, 92 (10), pp 1700–1704. The Electrochemical Pen (EChemPen) was developed as an...
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Bipolar Electrografting on the Inner Wall of Carbon Nanotubes
Wednesday, 23 September 2015
C. Kumsapaya, J. Limtrakul, A. Kuhn, D. Zigah, C. Warakulwit. ChemElectroChem, 2016, 3, 410-414. Vertically aligned carbon nanotubes were grown over the inner wall of the pores of an anodic aluminum...
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Single-Step Screening of the Potential Dependence of Metal Layer Morphologies Along Bipolar Electrodes
Monday, 07 September 2015
G. Tisserant, J. Gillion, J. Lannelongue, Z. Fattah, P. Garrigue, J. Roche, D. Zigah, B. Goudeau, A. Kuhn and L. Bouffier.  ChemElectroChem, 2016, 3, 387-391. The preparation of surface...
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Enantioselective Recognition of DOPA by mesoporous Platinum imprinted with Mandelic acid
Friday, 24 July 2015
T. Yutthalekha, C. Warakulwit, J. Limtrakul, A. Kuhn Electroanalysis, 2015, Special Issue Advanced Materials, in press Chiral imprinted mesoporous platinum was electrochemically synthesized in the...
Bottom-up Generation of Miniaturized Coaxial Double Electrodes with tunable Porosity
Friday, 24 July 2015
A. Karajić, S. Reculusa, M. Heim, P. Garrigue, S. Ravaine, N. Mano, A. Kuhn Adv. Mater. Interfaces, 2015, in press We report the bottom-up design of a fully integrated and miniaturized...
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3D electrogenerated chemiluminescence: from surface-confined reactions to bulk emission
Thursday, 11 June 2015
M. Sentic, S. Arbault, L. Bouffier, D. Manojlovic, A. Kuhn and N. Sojic.   Chem. Sci., 2015, 6, 4433-4437.   Among luminescence techniques, electrogenerated chemiluminescence (ECL) provides...
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Synthesis of conducting asymmetric hydrogel particles showing autonomous motion
Thursday, 28 May 2015
A. Srinivasan, J. Roche, V. Ravaine and A. KuhnSoft Matter, 2015, 11, 3958-3962 In the present work, we introduce a new approach for the synthesis of asymmetric particles made from electrically...
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Shearforce Positioning of Nanoprobe Electrode Arrays for Scanning Electrochemical Microscopy Experiments
Tuesday, 12 May 2015
C. Adam, F. Kanoufi, N. Sojic and M. Etienne. Electrochim. Acta, 2015, in press. Shearforce detection was applied to the controlled positioning of nanotip arrays at air/solid and liquid/solid...
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Generation of Metal Composition Gradients by Means of Bipolar Electrodeposition
Wednesday, 18 March 2015
G. Tisserant, Z. Fattah, C. Ayela, J. Roche, B. Plano, D. Zigah, B. Goudeau, A. Kuhn and L. Bouffier.  Electrochim. Acta, 2015, 179, 276-281. Bipolar electrochemistry is an unconventional...
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Effects of 50 Hz Magnetic Fields on Gap Junctional Intercellular Communication in NIH3T3 Cells
Wednesday, 18 February 2015
Y. Percherancier, B. Goudeau, R. Charlet de Sauvage, F. Poulletier de Gannes, E. Haro, A. Hurtier, N. Sojic, I. Lagroye, S. Arbault, and B. Veyret Bioelectromagnetics, 2015, 36, 4, 287-293. The...
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Synthesis of Multivalent Silica Nanoparticles combining both Enthalpic and Entropic Patchiness
Friday, 16 January 2015
C. Hubert, C. Chomette, A. Désert, M. Sun, M. Treguer, S. Mornet, A. Perro, E. Duguet, S. Ravaine Faraday Discuss., 2015, 181, 139-146 Silica particles with a controlled number of entropic patches,...
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Wednesday, 10 December 2014
V. Eßmann, D. Jambrec, A. Kuhn, W. Schuhmann Electrochem. Comm. 2015, 50, 77–80. The range of potential analytes for bipolar electrochemistry can be significantly extended by modification of...
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