Biocompatible and Biofunctional porous electrodes for miniaturized enzymatic Biofuel cells

The objective of our work is to design a fully integrated, extremely miniaturized and perfectly biocompatible glucose/O2 biofuel cell (BFC) as an in-vivo source of electricity that may power for example, a subcutaneously implanted, continuous glucose monitor for diabetes management.

However, numerous challenges have to be addressed before the implantation of such devices and they are the reason for this multidisciplinary proposal. Operating such BFC at high power density is challenging because it requires a large number of enzymes efficiently wired to the anode or the cathode and a fast enzyme turnover rate. It also requires that mass transport of products and reactants to/from the electrodes not being limited by diffusion and that the size of the BFC is small enough in order to be eventually implanted. May be the most crucial aspect in this context is to ensure also a perfect biocompatibility of such a device, thus preventing foreign body reactions or other harmful effects in the body.

Within this context, we wish to address all these issues SIMULTEANOUSLY based on the synergy between the know-how of the different partners.