Heim M., Rousseau L., Reculusa S., Urbanova V., Mazzocco C., Joucla S., Bouffier L., Vytras K., Bartlett P., Kuhn A., Yvert B.
Journal of Neurophysiology 2012, 15, 1793-1803.

Microelectrode arrays (MEAs) are appealing tools to probe large neural ensembles and build neural prostheses. Microelectronics microfabrication technologies now allow building high-density MEAs containing several hundreds of microelectrodes. However, several major problems become limiting factors when the size of the microelectrodes decreases. In particular, regarding recording of neural activity, the intrinsic noise level of a microelectrode dramatically increases when the size becomes small (typically below 20-μm diameter). Here, we propose to overcome this limitation using a template-based, single-scale meso- or two-scale macro-/mesoporous modification of the microelectrodes, combining the advantages of an overall small geometric surface and an active surface increased by several orders of magnitude. For this purpose, standard platinum MEAs were covered with a highly porous platinum overlayer obtained by lyotropic liquid crystal templating possibly in combination with a microsphere templating approach. These porous coatings were mechanically more robust than Pt-black coating and avoid potential toxicity issues. They had a highly increased active surface, resulting in a noise level 3 times smaller than that of conventional flat electrodes. This approach can thus be used to build highly dense arrays of small-size microelectrodes for sensitive neural signal detection.

 

JNeurophys2012 TOC

Thumbnail Loget G., Roche J., Gianessi E., Bouffier L., Kuhn A.,J. Am. Chem.Soc. 2012, 134, 20033-20036. Based on the principles of bipolar electrochemistry, localized pH gradients are generated at the surface...
Thumbnail Sentic M., Loget G., Manojlovic D., Kuhn A., Sojic N.,Angew. Chem. Int. Ed. 2012, 51, 11284–11288. Swimmer in the dark: Propulsion of a conducting object is intrinsically coupled with light...
Thumbnail Fattah Z., Garrigue P., Lapeyre V., Kuhn A., Bouffier L.,J. Phys. Chem. C 2012, 116, 22021-22027. Asymmetric particles of various chemical compositions have attracted great attention because...
Thumbnail Zigah D., Rodriguez-Lopez P., Bard A. J.,Phys. Chem. Chem. Phys. 2012, 14, 12764-12772. Asymmetric particles of various chemical compositions have attracted great attention because of their...
Thumbnail Peyrard L., Dumartin M.-L., Chierici S., Pinet S., Jonusauskas G., Meyrand P., Gosse I.,J. Org. Chem. 2012, 77, 7023-7027. Cyclotriveratrylene analogues (CTVs) are supramolecular bowl-shaped...
Thumbnail Bouffier L., Gosse I., Demeunynck M., Mailley P.,Bioelectrochemistry 2012, 88, 103-109. We report here the electrochemical characterization of eight synthetic DNA intercalators based on the...
Thumbnail Loget G., Roche J., Kuhn A.,Adv. Mater. 2012, 24, 5111-5116. Cover article Janus particles have different features/chemistry on two opposite sides (see figure). So far, they have been obtained...
Thumbnail Loget G., Lee T.-C., Taylor R. W., Mahajan S., Nicoletti O., Jones S. T., Coulston R. J., Lapeyre V., Garrigue P., Midgley P. A., Scherman O. A., Baumberg J. J., Kuhn A.,Small 2012, 8,...
Thumbnail Heim M., Rousseau L., Reculusa S., Urbanova V., Mazzocco C., Joucla S., Bouffier L., Vytras K., Bartlett P., Kuhn A., Yvert B.Journal of Neurophysiology 2012, 15, 1793-1803. Microelectrode arrays...
Thumbnail Loget G., Kuhn A.,J. Mater. Chem. 2012, 22, 15457-15474. Feature article This review article highlights the most recent advances with respect to the preparation of Janus objects by bulk phase...
Thumbnail Loget G., Kuhn A.,Lab on a Chip 2012, 12, 1967-1971. Hot Paper, Cover Article We report for the first time the vertical propulsion of conducting beads in liquid filled capillaries by bipolar...
Thumbnail Destribats M., Lapeyre V., Sellier E., Leal Calderon F., Ravaine V., Schmitt V.,Langmuir 2012, 28, 3744-3755. We used soft microgels made of poly(N-isopropylacrylamide) (pNIPAM) of variable...
Thumbnail Lalo H., Bon Saint-Côme Y., Plano B., Etienne M., Walcarius E., Kuhn A.,Langmuir 2012, 28, 2323-2326. The elaboration of an original composite bimetallic macroporous electrode containing a...
Thumbnail Couedelo L., Vaysse C., Vaique E., Guy A., Gosse I., Durand T., Pinet S., Cansell M., Combe N.Journal of Nutrition 2012, 142, 70-75. Little is known about the ability of α-linolenic acid (Ln) to...
Thumbnail Heim M., Reculusa S., Ravaine S., Kuhn A.,Adv. Funct. Mater. 2012, 22, 538-545. Inside Cover Article Macroporous materials with a sophisticated architecture are obtained by electrochemical...
Thumbnail Bouffier L., Lister K. E., Higgins S. J., Nichols R. J., Doneux T.,J. Electroanal. Chem. 2012, 664, 80-87. The electrochemistry of proton coupled electron transfer phenomena is an important...
Thumbnail Heim M., Yvert B., Kuhn A.,J. Physiology - Paris 2012, 106, 137-145. Microelectrode arrays (MEAs) are widely used tools for recording and stimulating extracellular neuronal activity. Major...