Messager L., Portecop N., Hachet E., Lapeyre V., Pignot-Paintrand I., Catargi B., Auzély-Velty R., Ravaine V.,
J. Mater. Chem. B 2013, 1, 3369-3379.

We present the preparation of nanogels made of hyaluronic acid (HA) with a well-controlled structure. To this end, HA precursors with polymerizable methacrylate groups (HA-MA) were confined within water-in-oil nanoemulsion droplets as nanoreactors and further photopolymerized under UV. Particular attention was paid to the preparation of a stable nanoemulsion template with a homogeneous droplet size. Upon UV irradiation of the emulsion containing HA-MA, crosslinked HA-MA particles with a well-defined size were obtained. Moreover, by varying the photopolymerization conditions, i.e. the number of received photons, we could control the conversion rate of the polymerization, as proved by 1H-NMR. Nanogels with controlled cross-linking densities were thus obtained. Not only could their crosslinking densities be controlled by the number of incident photons, but also by the degree of methacrylation (DM) of HA-MA derivatives. In addition, the swelling properties of the nanogels depended on external factors, showing their pH and ionic strength responsiveness. We show that these structures were highly biocompatible, stable under storage and enzymatically biodegradable, which opens the route for their application as drug delivery systems. Finally, insulin was loaded in the nanogels and its pH-dependent release was demonstrated. This versatile method of nanogel preparation, which can be applied to every type of hydrophilic precursor, offers a potential synthetic route to design other types of fully biocompatible drug delivery systems.

 

JMaterChemB2013 p3369 TOC

Thumbnail Schmitt V., Ravaine V.,Curr. Opin. Colloid Interface Sci. 2013, 18, 532–541. Review Colloidal gel particles called microgels have shown their ability to adsorb at an oil–water interface and...
Thumbnail Husken N., Taylor R. W., Zigah D., Taveau J.-C., Lambert O., Scherman O. A., Baumberg J. J., Kuhn A.,Nano Lett. 2013, 13, 6016–6022. One-dimensional (1D) nanoparticle chains with defined...
Thumbnail Chen K., Adam C., Sojic N., Schmittel M.,RSC Adv. 2013, 33, 24140–24145. For remote Hg2+ detection, an array of nanotips was covalently functionalised using a versatile photochemical approach. After...
Thumbnail Destribats M., Wolfs M., Pinaud F., Lapeyre V., Sellier E., Schmitt V., Ravaine V.,Langmuir 2013, 29, 12367–12374. This work reports a new evidence of the versatility of soft responsive...
Thumbnail Suraniti E., Kanoufi F., Gosse C., Zhao X., Dimova R., Pouligny B., Sojic N.,Anal. Chem. 2013, 85, 8902–8909. Editors' Highlight ! Latex micrometric beads are manipulated by optical tweezers in the...
Thumbnail Yiu H. H. P., Bouffier L., Boldrin P., Long J., Claridge J. B., Rosseinsky M. J.,Langmuir 2013, 29, 11354-11365. Iron (II,III) oxide Fe3O4 nanoparticles (25 and 50 nm NPs) are grafted with amine...
Thumbnail Fattah Z., Garrigue P., Goudeau B., Lapeyre V., Kuhn A., Bouffier L.,Electrophoresis 2013, 34, 1985-1990. The site selective electrodeposition of silver metal onto a conducting object such...
Thumbnail Vanhove E., Ben-Amor S., Charlot S., Colin D., Devin A., Rigoulet M., Sojic N., Sékli Belaïdi F., Launay J., Temple-Boyer P., Arbault S.,I.E.E.E., Proceedings of Transducers 2013, 1135-1138....
Thumbnail Loget G., Zigah D., Bouffier L., Sojic N., Kuhn A.Acc. Chem. Res.2013, 46,2513-2523. Bipolar electrochemistry, a phenomenon which generates an asymmetric reactivity onthe surface of...
Thumbnail Shu Q., Adam C., Sojic N., Schmittel M.,Analyst 2013, 138, 4500-4504. An electrochemiluminescent sensing scheme is presented for remote detection of Hg2+ through an ITO-coated nanostructured...
Thumbnail Messager L., Portecop N., Hachet E., Lapeyre V., Pignot-Paintrand I., Catargi B., Auzély-Velty R., Ravaine V.,J. Mater. Chem. B 2013, 1, 3369-3379. We present the preparation of nanogels made...
Thumbnail Suraniti E., Vajrala S. R., Goudeau B., Bottari S., Rigoulet M., Devin A., Sojic N., Arbault S.,Anal. Chem. 2013, 85, 5146-5152. It is now demonstrated that mitochondria individually function...
Thumbnail Descamps E., Duroure N., Deiss F., Leichlé T., Adam C., Mailley P., Aït-Ikhlef A., Livache T., Nicu L., Sojic N.,Lab on a Chip 2013, 13, 2956-2962. Optical nanotip arrays fabricated on etched...
Thumbnail Pinaud F., Russo L., Pinet S., Gosse I., Ravaine V., Sojic N.,J. Am. Chem. Soc. 2013, 135, 5517-5520. The electrochemistry, photoluminescence and electrogenerated chemiluminescence of...
Thumbnail Fattah Z., Roche J., Garrigue P., Zigah D., Bouffier L., Kuhn A.,Chem. Phys. Chem. 2013, 14, 2089-2093. Blue light on a Janus rod: Prussian Blue (PB) is locally generated in an asymmetric...
Thumbnail Ayela C., Lalo H., Kuhn A.,Appl. Phys.Lett. 2013, 102, 053501. The purpose of the present work is the introduction of a combined bottom-up and top-down approach to generate 3-dimensional gold...
Thumbnail Mokrushina A. V., Heim M., Karyakina E. E., Kuhn A., Karyakin A. A.,Electrochem. Comm. 2013, 29, 78-80. We report on the successful modification of macroporous microelectrodes with the...
Thumbnail Ben-Amor S., Devin A., Rigoulet M., Sojic N., Arbault S., Electroanalysis 2013, 25, 656-663. Hydrogen peroxide is a major bio-active molecule produced by mitochondria during aerobic metabolism....
Thumbnail Kumsapaya C., Bakai M.-F., Loget G., Goudeau B., Warakulwit C., Limtrakul J., Kuhn A., Zigah D.,Chemistry - A European Journal 2013, 19, 1577-1580. Glassy carbon beads are selectively...
Thumbnail Heim M., Wattanakit C., Reculusa S., Warakulwit C., Limtrakul J., Ravaine S., Kuhn A.,Electroanalysis 2013, 25, 888-894. Hierarchically ordered macro-mesoporous Pt films have been synthesized on...
Thumbnail Bouffier L., Kuhn A., Nanoscale 2013, 5, 1305-1309. The control of motion of small objects is an emerging research area. Their design strongly depends on the strategy chosen to trigger the...
Thumbnail Valappil S. P., Yiu H. H. P., Bouffier L., Hope C. K., Evans G., Claridge J. B., Higham S. M., Rosseinsky M. J., Dalton Trans. 2013, 42, 1778-1786. Gallium has emerged as a new therapeutic agent...
Thumbnail Bon Saint Côme Y., Lalo H., Wang Z., Kohring G.W, Hempelmann R., Etienne M., Walcarius A., Kuhn A., Electroanalysis 2013, 25, 621-629. Gold nanoparticles have been co-encapsulated with d-sorbitol dehydrogenase...