S. Assavapanumat, T. Yutthalekha, P. Garrigue, B. Goudeau, V. Lapeyre, A. Perro, N. Sojic, C. Wattanakit, A. Kuhn

Angew. Chem. Int. Ed. 58 (2019) 3471 (Back Cover)

see also CNRS press release

Concepts leading to single enantiomers of chiral molecules are of crucial importance for many applications, including pharmacology and biotechnology. Recently, mesoporous metal phases encoded with chiral information have been developed. We propose here to fine-tune the enantioaffinity of such structures by imposing an electric potential, which can influence the electrostatic interactions between the chiral metal and the target enantiomer. This allows increasing the binding affinity and thus the discrimination between two enantiomers. The concept is illustrated by generating chiral encoded metals in a microfluidic channel via the reduction of a platinum salt in the presence of a liquid crystal and L-tryptophan as a chiral model template. After removal of the template molecules, the modified microchannel retains a pronounced chiral character. Its chiral recognition efficiency can be fine-tuned by applying a suitable potential to the metal phase. This enables the separation of both components of a racemate flowing through the channel. The approach constitutes a promising and complementary strategy in the frame of chiral discrimination technologies.

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Thumbnail S. Assavapanumat, T. Yutthalekha, P. Garrigue, B. Goudeau, V. Lapeyre, A. Perro, N. Sojic, C. Wattanakit, A. Kuhn Angew. Chem. Int. Ed. 58 (2019) 3471 (Back Cover) see also CNRS press release...
Thumbnail S. Voci, B. Goudeau, G. Valenti, A. Lesch, M. Jović, S. Rapino, F. Paolucci, S. Arbault, N. Sojic J. Am. Chem. Soc., 140,2018, 14753-14760 Herein is reported a surface-confined microscopy based...
Thumbnail Hanan Al-Kutubi, Silvia Voci, Liza Rassaei, Neso Sojic, Klaus Mathwig Chem .Sci., 9, 2018, (2018 Chemical Science HOT Article Collection) Microfabricated nanofluidic electrochemical devices offer a...
Thumbnail L. Bouffier, S. Arbault, A. Kuhn, N. Sojic Techniques de l’Ingénieur. 2018. P156 Les mesures sélectives et sensibles dans des échantillons complexes tels que l’urine ou le sang sont devenues des outils...
Thumbnail H. Labie, A. Perro, V. Lapeyre, B. Goudeau, B. Catargi, R. Auzély, V. Ravaine Journal of Colloid and Interface Science 535 (2019) 16–27 A simple route to deliver on demand hydrosoluble molecules such...
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Thumbnail L. Zhang, B. Gupta, B. Goudeau, N. Mano, A. Kuhn J. Am. Chem. Soc 140 (2018) 15501 Collecting electrochemical information concerning the presence of molecules in a solution is usually achieved by measuring...
Thumbnail L. Adam, A. Kuhn Techniques de l'Ingénieur (2019)Ref:IN189 V1 Les molécules chirales sont d’un grand intérêt dans un certain nombre de domaines tels que la médecine, la biologie ou encore la chimie....
Thumbnail J.-P. Douliez, A. Perro, J.-P. Chapel, B. Goudeau and L. Béven Small 2018, 1803042 A template-free all-aqueous bulk preparation of robust hollow capsules having a gelatin shell from all-in-water...
Thumbnail G. Salinas, B. A. Frontana-Uribe, S. Reculusa, P. Garrigue, A. Kuhn Anal.Chem. 90 (2018) 11770 Highly ordered macroporous electrodes of the conducting polymer poly-3,4-ortho-xylendioxythiophene...
Thumbnail T. D. Le, L. Zhang, S. Reculusa, G.Vignoles, N. Mano, A. Kuhn, D. Lasseux ChemElectroChem 6 (2018) 173 This article reports on a procedure to predict the optimal thickness of cylindrical porous...
Thumbnail A. de Poulpiquet, B. Goudeau, P. Garrigue, N. Sojic, S. Arbault, T. Doneux, L. Bouffier. Chem. Sci. 2018, 9, 6622-6628. The coupling between electrochemistry and fluorescence confocal laser scanning...
Thumbnail V. Pirenne, G. Kurtay, S. Voci, L. Bouffier, N. Sojic, F. Robert, D. M. Bassani, Y. Landais. Org. Lett. 2018, 20 (15), 4521-4525. Eosin-Y (EY)-mediated alkylsulfonyl cyanation of olefins was shown...
Thumbnail I. Hernández Delgado, S. Pascal, C. Besnard, S. Voci, L. Bouffier, N. Sojic, J. Lacour. Chem. Eur. J. 2018, 24 (40), 10186-10195. A series of nine C‐functionalized cationic diazaoxa triangulene...
Thumbnail E. Suraniti, P. Merzeau, J. Roche, S. Gounel, A. G. Mark, P. Fischer, N. Mano, A. Kuhn Nature Comm. 2018, 9:3229 see also CNRS press release Chemical systems do not allow the coupling of energy from...
Thumbnail D. Kos, H. P. A. G. Astier, G. D. Martino, J. Mertens, H. Ohadi, D. De. Fazio, D. Yoon, Z. Zhao, A. Kuhn, A. C. Ferrari, C. J. B. Ford, J. J. Baumberg Small 14 (2018) 1801599 Nanoactuators are a key...
Thumbnail Ruigrok, H.J., Arnaud-Cormos D., Hurtier A., Poque-Haro E., Poulletier de Gannes F., Ruffié G., Bonnaudin F, Lagroye I., Sojic N., Arbault S., Lévêque P., Veyret B. and Percherancier Y. Radiation...
Thumbnail Girard F., Peret M., Dumont N., Badets V., Blanc S., Gazeli K., Noël C., Belmonte T., Marlin L., Cambus J.P., Simon G., Sojic N., Held B., Clément F. and Arbault S. Phys. Chem. Chem. Phys., 2018, 20,...
Thumbnail Lefrançois P., Goudeau B., Arbault S. Integrative Biology, 2018, in press Phospholipid Giant Unilamellar Vesicles (GUVs) are usually prepared by electroformation in water, that is in a...
Thumbnail E. Suraniti, A.G. Mark, J. Roche, H. Richter, A. Kuhn, P. Fischer, N. Mano L’Actualité Chimique 2018, 427-428,127-128 Une micro-source d’énergie intégrée permettrait à des implants biomédicaux...